Theophylline is widely used in pediatric patients for the treatment of asthma. To achieve adequate brochodilation and avoid side effect, it is generally accepted that the serum theophylline concentration should be maintained between 10 and
20㎍/ml.
Clinical effectiveness and toxicity are clearly related to some factors which might later theophylline pharmacoknetics. Fever or respiratory infection, although it seems tobe elevated serum level of theophylline, conflicting reports still appear
in
journals.
Thus we studies retrospectively theophylline clearance, serum drug concentration(SDC) half life, volume distribution in 132 asthmatic children who were admitted to our hospital and received intravenous aminophylline and oral theophylline and
tried
to
reveal the effect of fever of respiratory infection.
@ES The results are as follows:
@EN 1) In febrile children between 6month and 1 year old, there was no difference in theophylline serum concentration, half life, volume distribution, clearance.
2) In febrile respiratory infection children between 6month and 1 year old, there was no difference in theophylline serum concentration, half life, volume distribution, clearance.
3) in febrile children, febrile respiratory children over 1year old, theophylline serum concentration was significantly increased, volume distribution were significantly lower than without febrile, febrile respiratory infection. But, there was
no
difference in theophylline half life and clearance.
As a result, it is suggested that fever, may decrease theophylline volume distribution and increase theophylline serum concentration.
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